Born in 1897 in Ronta di Cesena, a small but ancient town in the province of Forlì with a primarily agricultural economy, Natale was forced to leave the city in 1935 with his wife and three young daughters. Raised in an anti-Fascist family—first socialist and later joining the PCdI after 1921—he lived under the constant threat of violence from the Blackshirts. He worked as a mechanical fitter at Falck Concordia, where he became active in the 184th SAP Brigade "Luciano Migliorini."

Athos Gori, who was arrested alongside him and others at the factory, described their activities: "In the ironworks, we had set up an organization to send young draft evaders and wanted men to the mountains." On December 6, 1943, they were called to the Management office and accused of being promoters of the Communist Party. This was the first wave of repression against the Milanese Resistance.

After being held in Monza prison and undergoing initial interrogations at the Hotel Regina, where they were beaten, they were kept in solitary confinement at San Vittore for three months. On March 4, they were taken to Platform 21 in Milan and sent to Mauthausen in sealed wagons. With him were Francesco Ghianda, Luciano Morganti, Eliseo Picardi, and Giovanni Tamagni—all destined to die in the camps.

Natale was initially transferred to Gusen but was soon separated from his comrades; based on his profession, he was sent to the workshops of the Schwechat subcamp to build aircraft parts. Finally, he was sent to Wien-Floridsdorf, where he died at the age of 47 after seven months of deprivation. Nazi documentation cites "circulatory failure" as the cause. His family only received official word of his death in 1948.